Type 1 Diabetes

Oberholzer-Head-Shot

Researcher & Surgeon Dr. Jose Oberholzer

By Larry Atseff

In our discussions with Dick Portillo and the success of his restaurant chain, we learned how important it was for Sharon, his childhood sweetheart and wife of 62 years, to be constantly by his side. We also learned that in 1997, it was discovered that she had Type 1 diabetes. In the course of treatment, they have learned the following:

1 Chicago is a leading center for the treatment of Type 1 and Type 2 diabetes.

2 At the forefront in treating Type 1 diabetes is Doctor Jose Oberholzer.

3 The group he founded, the Chicago Diabetes Project, is an international research collaboration that is focused on “islet transplantation”, a promising technique in dealing with Type 1.

4 In fact, islet transplantation has been effective in treating Sharon. As a result, Dick has helped fund Dr. Oberholzer’s efforts, and wants more people to know about Oberholzer’s important work.

How Type 1 and Type 2 Diabetes differ

Of 26.8 million Americans diagnosed with diabetes, about 1.6 million have Type 1. Types 1 and 2 both cause high blood sugar and have insulin as the problem. Insulin is a hormone that unlocks cells to let in blood sugar, and that creates energy. You can’t live without insulin. If you have Type 2, your body makes insulin, but can’t use it properly. If you have Type 1, your body doesn’t make enough of it. The pancreas stops making it, as the body’s immune system mistakenly attacks healthy cells in the pancreas. Without insulin, sugar builds up in the blood and can damage your internal organs, including your heart, kidneys, eyes, nervous system, and other parts of the body. Obviously, these conditions can become life-threatening. Type 1 is extremely challenging, because, to this day, doctors are still not sure why the body doesn’t make enough insulin. While much of the medical community continues to try and determine the cause, techniques on controlling the disease with regular insulin injections or use of an insulin pump have become the prevalent treatments for Type 1.

The Chicago Diabetes Project and Dr. Oberholzer have put their focus on “islet transplantation” as a way to go further, and actually reverse Type 1 and enable the body to produce insulin naturally. Certain islet transplantation trials are showing that this approach is able to produce insulin naturally so well, some patients are actually living insulin-free. Islets are clusters of cells found in the pancreas that work together to regulate blood sugar. In an islet transplant, doctors take healthy islets from the pancreas of an organ donor, and inject them into someone with Type 1 diabetes. Now that islet transplantation is shown to work, scientists are looking for ways to make the technique more widely available, and at lower costs. In one approach, scientists focus on the transplant site. While the liver is the traditional site for islet transplantation, this location is not ideal. Other sites and options are being looked at. For example, researchers are looking at a bio-engineered platform that works like an artificial pancreas. Scientists are also looking for ways to sustain the islets’ long-term survival and protecting them from the autoimmune attacks that caused Type 1 diabetes in the first place.

Options include creating barriers to protect the cells, or even adding oxygen to transplant sites. Researchers are even investigating how to increase the supply of islets available for transplant, enabling the body to recreate a patient’s own pancreatic cells, so cells don’t have to be taken from a donor. This includes the use of lab created embryonic stem cells that, in turn, become islets for transplanting to a Type 1 diabetic. Dr. Oberholzer and his associates are constantly looking at other ways to make islet transplantation more effective and widespread.

For more information, go to chicagodiabetesproject.org

Author

Executive Chef Stephen Langlois

Feeding His Passion: Newly appointed Chef Stephen takes the helm at The Westin Chicago Lombard

The Blue Swallow Motel in Tucumcari, NM

Celebrating A Century of Open Road: Now in its 100th year, this slice of Americana still beckons travelers

Tely Nagle, Drake Hotel Proprietor, in the Romanesque gardens
Photo by Victor Hilitski

Welcome In! The Drake Oak Brook’s elegance and charm are back to stay

ATJMAH_CM_2223

Striking the Right Note: The Chicago Youth Orchestra shapes the lives of aspiring young musicians

The camaraderie of the volunteers often keeps them involved after their student graduates

Always Boosting: Hinsdale Central’s Booster Club helps fill gaps in student activity and athletic budgets

Anne Schultz, MD, FACP Cindy Lagone, MD, FACP

Authentic Internal Medicine: Building relationships with patients and the community

Hair loss problem after covid search Instagram Post Minimalist -

Is hair loss on your mind? Reclaim Your Crowning Glory

Kristina and Matthew Bailey began reading books to their son, Owen when he was six months old— they haven’t stopped.
Owen turned 4 in June and recently received an award from the Clarendon Hills Public Library for having had 1,000 books read to him before starting kindergarten.

The library’s 1,000 Books Before Kindergarten Challenge is one of a few reading challenge programs offered in Clarendon Hills, where the Bailey family has lived for the past 2 1/2 years.
Kristin Bailey said she saw an ad about the 1,000 Books Before Kindergarten Challenge and decided it was a good fit for Owen.

“He’s always been really into books,” Bailey said. “He had a natural interest in books at nine months old. That’s when COVID started, and he didn’t get out much, so reading books to him worked out very well. He’s a naturally curious kid, and imagination-building is important. The reading allows him to learn and explore new things, and he really wants to learn to read now.”

Krista Devlin, the Clarendon Hills library’s youth services librarian, said there’s a specific reason The Friends of the Library-sponsored 1,000 Books Before Kindergarten Challenge was started in 2022.

“Reading aloud to a child is one of the best ways to help develop important early literacy skills, which will prepare them for kindergarten,” Devlin said. “It is also a great way to bond with your child and to encourage a love of reading.”

Devlin said Owen was the second child to reach the challenge of having 1,000 books read to him before starting kindergarten. He was awarded a certificate, a crown, and his picture was taken to recognize his accomplishment.

Bailey, who said she is “a big reader,” said her family usually goes to the library once a week. Reading three books each night to Owen, along with a book before nap time, is the household normal.

“Consistency in our routine has been good and is important,” she said, adding that Owen’s two sisters, ages 2 1/2 and 1

An open book: Clarendon Hills four-year-old earns library recognition

Charlie Tomfohrde and his array of house plants for sale at the Hinsdale Farmers Market

A Budding Entrepreneur: Charlie Tomfohrde’s plant business continues to grow

Terri Doney (left) and co-founder Barb Thayer are “sisters” in the group, My Breast Cancer Sisters

Breast Cancer survivors: Hinsdale area group looking for others to help

Maxx Klein and Jack Klein

Airoom’s New Design Space Maxx and Jack Klein take the helm of their family’s business

IMG_4543

Oak Brook Bath & Tennis Club A Tennis Player’s Dream